Protein Modification Reagents
eMolecules 2055103-66-5 | Carboxyrhodamine 110-PEG4-alkyne | Broadpharm | MFCD30458035 | 587.629 | C32H33N3O8 | 85.000 | Nc1ccc2c(-c3ccc(cc3C(O)=O)C(=O)NCCOCCOCCOCCOCC#C)c3ccc(=N)cc3oc2c1 | 25mg | 340377112
Carboxyrhodamine 110-PEG4-alkyne | Broadpharm | 2055103-66-5 | MFCD30458035 | 587.629 | C32H33N3O8 | 85.000 | Nc1ccc2c(-c3ccc(cc3C(O)=O)C(=O)NCCOCCOCCOCCOCC#C)c3ccc(=N)cc3oc2c1 | 25mg | 340377112
Cayman Chemical VH 032 LInker 1 100mg
A PROTAC precursor; has been used in the synthesis of PROTACs targeting TEAD in cancer cells
Medchemexpress LLC 5,8,11,14-tetraoxa-2-azahexadecanedioic acid, 1-(9H-fluoren-9-yl)methyl ester | 437655-95-3 | MFCD26142981 | 99.5% | 473.52 g·mol⁻¹ | C25H31NO8 | 1 G
Fmoc-NH-PEG4-CH2COOH is an Fmoc-protected PEG4 linker bearing a terminal carboxylic acid. It is used as a building block in peptide synthesis, and in the design of antibody-drug conjugate (ADC) and PROTAC linkers, providing a short hydrophilic spacer and an Fmoc-protected amine for orthogonal coupling chemistry.
- Provides an Fmoc-protected amine for orthogonal deprotection and coupling.
- Contains a PEG4 spacer to increase solubility and flexibility.
- Terminal carboxylic acid enables standard amide bond formation.
- Solid powder form suitable for storage and handling in synthesis workflows.
- Commonly used in medicinal chemistry for linker and conjugation strategies.
Medchemexpress LLC Ma-PEG4-VC-PAB-DMEA-duocarmycin DM | 99.8% | 1381.96 g/mol | C68H89ClN12O17 | 5 MG
MA-PEG4-VC-PAB-DMEA-duocarmycin DM is a drug-linker conjugate intended for use in the construction of antibody-drug conjugates (ADCs). The cytotoxic payload is a DNA minor-groove alkylator; the product is supplied for research use only and includes analytical documentation (COA, HNMR, RP-HPLC).
- High purity suitable for research applications.
- Contains a duocarmycin DM DNA minor-groove alkylator payload.
- Solid, white to off-white appearance for easy handling.
- Available in small research sizes for early-stage studies.
- Analytical documentation and safety data available.
- Recommended to store protected from light and under inert atmosphere.
Medchemexpress LLC Bis-PEG4-PFP ester | 1314378-12-5 | 97.0% | 10 G
Bis-PEG4-PFP ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker, one for an E3 ubiquitin ligase and another for a target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. This product is for research use only.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Exploits the ubiquitin-proteasome system
- Enables selective degradation of target proteins
- For research use only
Medchemexpress LLC 3,6,9,12-Tetraoxatetradecane-1,14-diamine | 68960-97-4 | 98.0% | 236.31 | 250 MG
Amino-PEG4-C2-amine is a PEG-based (4 units) PROTAC linker that can be used in the synthesis of PROTACs.
- Peg-based (4 units) protac linker
- Used in the synthesis of protacs
eMolecules Biotin-PEG3-Mal | 1431618-70-0 | MFCD26142993 | 1g
Broadpharm | Biotin-PEG3-Mal | 1g | 309209108 | BP-22148 | 97.000 | 1431618-70-0 | MFCD26142993 | 569.670 | C25H39N5O8S
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eMolecules Building Block Tool
eMolecules 1008402-47-8 | Bis-Mal-PEG3 | Broadpharm | MFCD22683311 | 494.501 | C22H30N4O9 | 98.000 | O=C(CCN1C(=O)C=CC1=O)NCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 250mg | 200183412
Bis-Mal-PEG3 | Broadpharm | 1008402-47-8 | MFCD22683311 | 494.501 | C22H30N4O9 | 98.000 | O=C(CCN1C(=O)C=CC1=O)NCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 250mg | 200183412
eMolecules 2698339-32-9 | Methyltetrazine-amido-bis-(carboxyethoxymethyl)-methane | Broadpharm447.448 | C20H25N5O7 | 95.000 | Cc1nnc(nn1)-c1ccc(CC(=O)NC(COCCC(O)=O)COCCC(O)=O)cc1 | 50mg | 649280885
Methyltetrazine-amido-bis-(carboxyethoxymethyl)-methane | Broadpharm | 2698339-32-9447.448 | C20H25N5O7 | 95.000 | Cc1nnc(nn1)-c1ccc(CC(=O)NC(COCCC(O)=O)COCCC(O)=O)cc1 | 50mg | 649280885
Creative Pegworks 4-Arm PEG-Amine, MW 20k, 1 g
4-Arm PEG-Amine is a multiarm PEG derivative with amine groups at each terminal of the four arms connected to one pentaerythritol core. The reactive primary amine or NH2 group can rapidly react with activated carboxyl acid such as NHS ester to form stable amide bonds.
Medchemexpress LLC DBCO-PEG2-acid | 2304558-25-4 | ≥95.0% | C26H28N2O6 | 250 MG
DBCO-PEG2-acid is a PEG-based PROTAC linker designed for synthesizing PROTACs. It acts as a click chemistry reagent, featuring a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. PROTACs typically comprise two distinct ligands connected by a linker, where one targets an E3 ubiquitin ligase and the other targets the protein of interest, enabling selective degradation through the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Click chemistry reagent
- Incorporates a DBCO group
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Used in the synthesis of PROTACs
- Leverages the intracellular ubiquitin-proteasome system
- Suitable for laboratory chemical applications
![eMolecules 858126-78-0 | DNP-PEG4-NHS ester | Broadpharm | MFCD13184987 | 528.471 | C21H28N4O12 | 98.000 | [O-][N+](=O)c1ccc(NCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)c(c1)[N+]([O-])=O | 1g | 550804146](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203167.JPG-250.jpg)
eMolecules 858126-78-0 | DNP-PEG4-NHS ester | Broadpharm | MFCD13184987 | 528.471 | C21H28N4O12 | 98.000 | [O-][N+](=O)c1ccc(NCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)c(c1)[N+]([O-])=O | 1g | 550804146
DNP-PEG4-NHS ester | Broadpharm | 858126-78-0 | MFCD13184987 | 528.471 | C21H28N4O12 | 98.000 | [O-][N+](=O)c1ccc(NCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)c(c1)[N+]([O-])=O | 1g | 550804146
Medchemexpress LLC Biotin-PEG4-Amide-C6-Azide | 1006592-62-6 | 99.1% | C27H49N7O7S | 1 G
Biotin-PEG4-Amide-C6-Azide is a PEG-based PROTAC linker used in the synthesis of PROTACs. This click chemistry reagent contains an azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN group molecules. PROTACs utilize the ubiquitin-proteasome system for selective protein degradation.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent with azide group
- Supports copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Facilitates selective degradation of target proteins
- For research use only
Medchemexpress LLC Thiol-PEG-CH2COOH | 95.0% | 100 MG
Thiol-PEG-CH2COOH (MW 5000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. These PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
- Solid appearance
- White to off-white color
- Average molecular weight of 5000
Medchemexpress LLC Acid-C2-PEG4-C2-NHS ester | 1343476-41-4 | 98.0% | 50 MG
Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker. It is utilized in the synthesis of PROTACs, which consist of two distinct ligands connected by a linker. One ligand targets an E3 ubiquitin ligase, and the other targets a specific protein. These PROTACs leverage the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- Molecular weight: 435.42
- Molecular formula: C18H29NO11
- Appears as a colorless to light yellow liquid
- Density: 1.30±0.1 g/cm3
- Soluble in DMSO at 100 mg/mL
- For research use only
- Available documentation includes data sheet, SDS, COA, HNMR, and MS